Essential Histology Topics for the ESEGH Exam: Your Visual Guide to Success! 🎯

Histology can make or break your score in the Gastroenterology and Hepatology SCE (ESEGH) exam! Mastering histological patterns and recognizing key diagnostic features is crucial for quick and accurate responses. Here’s your ultimate visual revision guide—highlighting the must-know histology topics you need to confidently ace your exam.

Luminal Gastroenterology

• Inflammatory Bowel Disease (IBD)

  • Ulcerative Colitis: Crypt abscesses, continuous inflammation, superficial mucosal involvement

  • Crohn’s Disease: Non-caseating granulomas, transmural inflammation, skip lesions

• Coeliac Disease

  • Villous atrophy, crypt hyperplasia, increased intraepithelial lymphocytes

• Microscopic Colitis

  • Collagenous colitis: Thickened subepithelial collagen band

  • Lymphocytic colitis: Increased intraepithelial lymphocytes

• Gastrointestinal Polyps

  • Adenomatous polyps: Dysplastic epithelium, tubular or villous architecture

  • Serrated polyps: Saw-tooth appearance, crypt dilatation

• Barrett's Esophagus

  • Intestinal metaplasia, goblet cells in esophageal epithelium

• Coeliac Disease

  • Villous atrophy, crypt hyperplasia, increased intraepithelial lymphocytes

Hepatology

• Cirrhosis & Fibrosis

  • Bridging fibrosis, regenerative nodules

• Hepatitis B & C

  • Interface hepatitis, lymphoid aggregates, ground-glass hepatocytes (HBV)

• Wilson’s Disease

  • Hepatocyte copper accumulation, Mallory-Denk bodies, periportal fibrosis

• Haemochromatosis

  • Iron deposition in hepatocytes (Prussian blue staining), fibrosis, and cirrhosis

• Autoimmune Liver Diseases

  • Primary Biliary Cholangitis (PBC): Granulomas, florid duct lesions

  • Primary Sclerosing Cholangitis (PSC): Concentric "onion-skin" fibrosis around bile ducts

• Alcoholic Liver Disease

  • Macrovesicular steatosis, Mallory-Denk bodies, ballooning degeneration, neutrophilic infiltration

• Non-Alcoholic Fatty Liver Disease (NAFLD/NASH)

  • Macrovesicular steatosis, ballooned hepatocytes, Mallory-Denk bodies

• Wilson's Disease

  • Steatosis, glycogenated nuclei, Mallory-Denk bodies

• Hepatocellular Carcinoma (HCC)

  • Trabecular pattern, pseudoacinar structures, bile production by tumor cells

  • 
    

Pancreatobiliary Diseases

• Acute Pancreatitis

  • Fat necrosis, neutrophil infiltration

• Chronic Pancreatitis

  • Fibrosis, calcification, loss of acinar cells

• Gallbladder Disease

  • Chronic cholecystitis: Rokitansky-Aschoff sinuses, fibrosis

• Pancreatic Cancer

  • Adenocarcinoma: Desmoplastic reaction, glandular formation

Miscellaneous

• Coeliac Disease

  • Villous atrophy, crypt hyperplasia, intraepithelial lymphocytosis

• Neuroendocrine Tumors

  • Positive for chromogranin and synaptophysin markers

  • 
    

Revision Tip: Leverage targeted histology notes and high-yield MCQs available at RevisionPro to enhance your visual diagnostic skills and exam performance.

🎯 Unlock your highest ESEGH score—register now at RevisionProSCE.com and master your revision with expert MCQs and high-yield notes! 🚀